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KMID : 0361420100340020179
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Journal of Korean Academy of Rehabilitation Medicine
2010 Volume.34 No. 2 p.179 ~ p.184
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Electrophysiological Changes after Botulinum Toxin Type A in Children with Cerebral Palsy
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Kim Seong-Woo
Shin Jung-Bin
Yoo Sung
Kim Hyoung-Seop
Nam Ji-Hyun
Song Sang-Hyuk
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Abstract
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Objective: To investigate the electrophysiological changes after botulinum toxin type A injection in children with cerebral palsy.
Method: Sixteen children with spastic cerebral palsy enrolled in the study. Botulinum toxin type A (Dysport?) was injected into gastrocnemius muscles. Electrophysiological assessments included the compound motor action potential of the tibial nerve, the sensory nerve action potential of the sural nerve, the H-reflex and the T-reflex before injection, and at 2 weeks and 4 weeks after the injection. Modified Ashworth scale was used to evaluate spasticity before, 2 weeks and 4 weeks after the injection.
Results: Modified Ashworth scale of the ankle decreased at 2 weeks and 4 weeks after injection. The amplitude of the H-reflex and Hmax/Mmax ratio decreased significantly at 4 weeks. The amplitude of the T-reflex decreased at 2 weeks and 4 weeks. The correlation between changes in modified Ashworth scale of the ankle and the changes in electrophysiological parameters at 4 weeks after injection were not significant.
Conclusion: The change in T-reflex is faster than the change of H-reflex and Hmax/Mmax ratio after botulinum toxin A injection in children with cerebral palsy. Electrophysiological tests could quantify the change in spasticity after botulinum toxin injection.
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KEYWORD
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Cerebral palsy, Spasticity, Botulinum toxin, H-reflex, T-reflex
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